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Question of the month
Question of the Month

Which autoantibody is associated with necrotizing autoimmune myositis and what is the characteristic histopathology feature of it?
Email your answer on or before 15 December, 2014 to: iraenewsletter@hotmail.com
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Best reply for the 'Question of the month-November

Is biologic combination treatment superior to conventional DMARDs combination in preventing rheumatoid arthritis structural joint damage?

Answer:

No. Recent studies (NEO-RACo trial)1 and meta-analysis2 suggest that conventional combination DMARDs are not inferior to biologic combination treatment in early RA.

References

  1. Rantalaiho V, et al. Targeted treatment with a combination of traditional DMARDs produces excellent clinical and radiographic long-term outcomes in early rheumatoid arthritis regardless of initial infliximab. The 5-year follow-up results of a randomised clinical trial, the NEO-RACo trial. Ann Rheum Dis. 2014;73(11):1954–1961.
  2. Graudal N, et al. Effect of combination therapy on joint destruction in rheumatoid arthritis: A network meta-analysis of randomized controlled trials. PLoS One 2014;9(9):e106408.