Practice Matters Adult-onset still disease: Manifestations, treatment, outcome, and prognostic factors in 57 patients. Gerfaud-Valentin M, et al. Medicine (Baltimore). 2014;93(2):91–99. This retrospective observational study was conducted to describe a cohort and identify the prognostic factors in adult-onset Still’s disease (AOSD). The median time to diagnosis was 4 months. The course of AOSD was monocyclic in 17 patients, polycyclic in 25, and chronic in 15. The assessment of glycosylated ferritin (GF) in 37 patients was correlated with early diagnosis. Nine F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans....... Early- versus late-onset systemic sclerosis: Differences in clinical presentation and outcome in 1037 patients. Alba MA, et al. Medicine (Baltimore). 2014;93(2):73–81. The Spanish Scleroderma Study Group recruited 1037 patients with a mean follow-up of 5.2±6.8 years. The study patients were classified into three groups: age ≤30 years (early onset), age between 31 and 59 years (standard onset), and age ≥60 years (late onset). They compared initial and cumulative manifestations, immunologic features and death rates. The early-onset group included 195 patients; standard-onset group, 651; and late-onset, 191 patients....... Clinical analysis of 56 patients with rhupus syndrome: Manifestations and comparisons with systemic lupus erythematosus: A retrospective case-control study. Li J, et al. Medicine (Baltimore). 2014;93(10):e49. In this analysis, 1.30% (56/4301) of hospitalized SLE patients had rhupus syndrome. The median disease duration was 8.0 years and 83.9% had RA onset. All rhupus patients showed radiological erosion in the joints. Compared with the control group, Rhupus patients had a longer disease duration, higher prevalence of anticyclic citrullinated peptide antibody and rheumatoid factor, higher incidence of symmetrical polyarthritis with more joint deformities....... Development and validation of the H Score, a score for the diagnosis of reactive hemophagocytic syndrome. Fardet L, et al. Arthritis Rheumatol. 2014;66(9):2613–2620. A multicenter retrospective cohort of 312 patients was used to construct and validate the reactive hemophagocytic syndrome diagnostic score, called the H Score. Nine variables [3 clinical (i.e., known underlying immunosuppression, high temperature, organomegaly), 5 biologic (i.e., triglyceride, ferritin, serum glutamic oxaloacetic transaminase, and fibrinogen levels, cytopenia), and 1 cytologic (i.e., hemophagocytosis features on bone marrow aspirate)] were retained in the H Score....... Disease characteristics and treatment patterns in veterans with rheumatoid arthritis and concomitant hepatitis C infection.. Patel R, et al. Arthritis Care Res (Hoboken). 2014 Sep 3 [Epub ahead of print]. These v registry data show the prevalence of 5.1% of concomitant HCV in rheumatoid arthritis. Analysis of these patients’ data shows that these patients have higher disease activity scores and more likely to be treated with prednisone and anti-TNF-α therapies and less likely to receive methotrexate compared to HCV-negative patients.......